The role of invariant natural killer T cells in experimental xenobiotic-induced cholestatic hepatotoxicity

Inflammation, especially the release of pro-inflammatory mediators, contributes to hepatocyte injury during cholestasis. Alpha-naphthylisothiocyanate (ANIT) is widely used in rodents to mimic clinical cholestasis. Lymphocytes have been reported to exacerbate ANIT - induced hepatotoxicity. However, w...

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Bibliographic Details
Main Authors: Cheng Nong, Mengzhi Zou, Rufeng Xue, Li Bai, Li Liu, Zhenzhou Jiang, Lixin Sun, Xin Huang, Luyong Zhang, Xinzhi Wang
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332219352011