Interplay between Epigenetics, Expression of Estrogen Receptor- α, HER2/ERBB2 and Sensitivity of Triple Negative Breast Cancer Cells to Hormonal Therapy

Interplay between Epigenetics, Expression of Estrogen Receptor- α, HER2/ERBB2 and Sensitivity of Triple Negative Breast Cancer Cells to Hormonal Therapy

Triple negative breast cancer (TNBC) cells are resistant to hormonal/targeted therapies. This study aims to investigate epigenetic differences between TNBC and other types of breast cancer and the effect of epigenetic modulation on the response of TNBC cells to hormonal therapy. Thus, we investigate...

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Bibliographic Details
Main Authors: Wafaa S Ramadan, Cijo George Vazhappilly, Ekram M Saleh, Varsha Menon, Aya M AlAzawi, Ahmed T El-Serafi, Wael Mansour, Raafat El-Awady
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Cancers
Subjects:
triple negative breast cancer
estrogen receptor alpha
human epidermal growth factor receptor-2
epigenetics
suberoylanilide hydroxamic acid
2′-deoxy-5-azacytidine
tamoxifen
Online Access:http://www.mdpi.com/2072-6694/11/1/13

Internet

http://www.mdpi.com/2072-6694/11/1/13

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