Enhanced Gut-Homing Dynamics and Pronounced Exhaustion of Mucosal and Blood CD4+ T Cells in HIV-Infected Immunological Non-Responders

Enhanced Gut-Homing Dynamics and Pronounced Exhaustion of Mucosal and Blood CD4+ T Cells in HIV-Infected Immunological Non-Responders

Immunological non-responders (INR), a subgroup of people living with HIV (PLHIV) who fail to restore CD4+ T cell numbers upon effective antiretroviral treatment, have impaired gut mucosal barrier function and an inferior clinical prognosis compared with immunological responders (IR). The contributio...

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Bibliographic Details
Main Authors: Kristina Berg Lorvik, Malin Holm Meyer-Myklestad, Kushi Kushekar, Charlotte Handeland, Asle Wilhelm Medhus, Marius Lund-Iversen, Birgitte Stiksrud, Dag Kvale, Anne Margarita Dyrhol-Riise, Kjetil Taskén, Dag Henrik Reikvam
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Immunology
Subjects:
HIV
immunological non-responder
PD1
CD4 T cell
TIGIT
gut-homing CD4+ T cell
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.744155/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.744155/full

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