Unusually strong temperature dependence of P2X3 receptor traffic to the plasma membrane

Unusually strong temperature dependence of P2X3 receptor traffic to the plasma membrane

ATP-gated P2X3 receptors are expressed by nociceptive neurons and participate in transduction of pain. Responsiveness of P2X3 receptors is strongly enhanced at high temperatures, suggesting a role for these receptors in temperature detection. Since sustained responsiveness depends on receptor traffi...

Full description

Bibliographic Details
Main Authors: Evgeny ePryazhnikov, Dmitriy eFayuk, Minna eNiittykoski, Rashid eGiniatullin, Leonard eKhiroug
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Pain
temperature
Receptor Trafficking
ligand gated receptors
P2X3 receptor
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2011.00027/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2011.00027/full

Similar Items