18F-FDG PET-CT for early detection of malignancies in patients with Li-Fraumeni Syndrome

PurposeTo evaluate the effectiveness of 18F-Fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) for detecting early cancer in carriers of germline TP53 mutation, the genetic defect underlying Li-Fraumeni and related syndromes (LFS/LFL) which predisposes to many forms...

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Main Authors: Sonia Tereza Santos Nogueira, Eduardo Nóbrega Pereira Lima, Amanda França Nóbrega, Ivone do Carmo Gonçalves Torres, Marcelo eCavicchioli, Pierre eHainaut, Maria Isabel Waddington Achatz
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-02-01
Series:Frontiers in Oncology
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Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00038/full