In-Silico Identified New Natural Sortase A Inhibitors Disrupt <i>S. aureus</i> Biofilm Formation

In-Silico Identified New Natural Sortase A Inhibitors Disrupt <i>S. aureus</i> Biofilm Formation

Sortase A (SrtA) is a membrane-associated enzyme that anchors surface-exposed proteins to the cell wall envelope of Gram-positive bacteria such as <i>Staphylococcus aureus</i>. As SrtA is essential for Gram-positive bacterial pathogenesis but dispensable for microbial growth or viability...

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Bibliographic Details
Main Authors: Kishore Reddy Venkata Thappeta, Li Na Zhao, Choy Eng Nge, Sharon Crasta, Chung Yan Leong, Veronica Ng, Yoganathan Kanagasundaram, Hao Fan, Siew Bee Ng
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
anti-biofilm activity
sortase A inhibitor
<i>Staphylococcus aureus</i>
MRSA
fibrinogen
molecular docking
Online Access:https://www.mdpi.com/1422-0067/21/22/8601

Internet

https://www.mdpi.com/1422-0067/21/22/8601

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