TRP Channels as Interior Designers: Remodeling the Endolysosomal Compartment in Natural Killer Cells

TRP Channels as Interior Designers: Remodeling the Endolysosomal Compartment in Natural Killer Cells

Cytotoxic lymphocytes, including natural killer (NK) cells and T cells are distinguished by their ability to eliminate target cells through release of secretory lysosomes. Conventional lysosomes and secretory lysosomes are part of the pleomorphic endolysosomal system and characterized by its highly...

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Bibliographic Details
Main Authors: Dennis Clement, Jodie P. Goodridge, Christian Grimm, Sandip Patel, Karl-Johan Malmberg
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Immunology
Subjects:
NK cell
TRP cation channel
secretory lysosomes
cytotoxic lymphocytes
mucolipin
calcium signaling
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00753/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00753/full

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