Huperzine A Ameliorates Cognitive Deficits in Streptozotocin-Induced Diabetic Rats

Huperzine A Ameliorates Cognitive Deficits in Streptozotocin-Induced Diabetic Rats

The present study was designed to probe the effects of Huperzine A (HupA) on diabetes-associated cognitive decline (DACD) using a streptozotocin (STZ)-injected rat model. Diabetic rats were treated with HupA (0.05 and 0.1 mg/kg) for seven weeks. Memory functions were evaluated by the water maze test...

Full description

Bibliographic Details
Main Authors:	Xiao-Yuan Mao, Dan-Feng Cao, Xi Li, Ji-Ye Yin, Zhi-Bin Wang, Ying Zhang, Chen-Xue Mao, Hong-Hao Zhou, Zhao-Qian Liu
Format:	Article
Language:	English
Published:	MDPI AG 2014-05-01
Series:	International Journal of Molecular Sciences
Subjects:	huperzine A diabetes-associated cognitive decline brain-derived neurotrophic factor oxidative stress inflammation apoptosis
Online Access:	http://www.mdpi.com/1422-0067/15/5/7667

Similar Items

Evaluation of cryptolepine and huperzine derivatives as lead compounds towards new agents for the treatment of human African Trypanosomiasis.
by: Oluwafemi, A.J., et al.
Published: (2010)

Huperzine A attenuates nonalcoholic fatty liver disease by regulating hepatocyte senescence and apoptosis: an in vitro study
by: Xiao-na Hu, et al.
Published: (2018-06-01)

Dissolving microneedles for transdermal delivery of huperzine A for the treatment of Alzheimer's disease
by: Qinying Yan, et al.
Published: (2020-01-01)

Huperzine A - An Interesting Anticholinesterase Compound from the Chinese Herbal Medicine
by: Jiří Patočka
Published: (1998-01-01)

Huperzine A and Huperzine B Production by Prothallus Cultures of <i>Huperzia selago</i> (L.) Bernh. ex Schrank et Mart
by: Wojciech J. Szypuła, et al.
Published: (2020-07-01)

Inhibition of Acetylcholinesterase in Different Structures of the Rat Brain Following Soman Intoxication Pretreated with Huperzine A
by: Lukas Capek, et al.
Published: (2007-11-01)

RNA-seq of aboveground sporophyte’s transcriptome of Huperzia serrata and transcriptional understanding of early steps associated with huperzine biosynthesis in forest
by: Qing-Zhong Peng, et al.
Published: (2020-12-01)

In Vitro Propagation, Huperzine A Content and Antioxidant Activity of Three Genotypic <i>Huperzia serrata</i>
by: Yan Yang, et al.
Published: (2021-05-01)

Huperzine A: is it an effective disease-modifying drug for Alzheimer’s disease?
by: Zhong Ming eQian, et al.
Published: (2014-08-01)

Self-microemulsifying drug delivery system for improving the bioavailability of huperzine A by lymphatic uptake
by: Fang Li, et al.
Published: (2017-05-01)

Huperzia serrata Extract ‘NSP01’ With Neuroprotective Effects-Potential Synergies of Huperzine A and Polyphenols
by: N. Callizot, et al.
Published: (2021-08-01)

Endophytic Fungal Community of <i>Huperzia serrata</i>: Diversity and Relevance to the Production of Huperzine A by the Plant Host
by: Lingli Cui, et al.
Published: (2021-02-01)

A new and fast method to obtain in vitro cultures of Huperzia selago (Huperziaceae) sporophytes, a club moss which is a source of huperzine A
by: Wojciech J. Szypuła, et al.
Published: (2013-12-01)

Huperzine A provides robust and sustained protection against induced seizures in Scn1a mutant mice
by: Jennifer C. Wong, et al.
Published: (2016-10-01)

Intranasal delivery of Huperzine A to the brain using lactoferrin-conjugated N-trimethylated chitosan surface-modified PLGA nanoparticles for treatment of Alzheimer’s disease
by: Meng QQ, et al.
Published: (2018-02-01)

Effects of the Hydroethanolic Extract of <i>Lycopodium selago</i> L. on Scopolamine-Induced Memory Deficits in Zebrafish
by: Mihai-Vlad Valu, et al.
Published: (2021-06-01)

Serum BDNF and GDNF in Chinese male patients with deficit schizophrenia and their relationships with neurocognitive dysfunction
by: Xiaowei Tang, et al.
Published: (2019-08-01)

Apelin-13 Suppresses Neuroinflammation Against Cognitive Deficit in a Streptozotocin-Induced Rat Model of Alzheimer’s Disease Through Activation of BDNF-TrkB Signaling Pathway
by: Huaiqing Luo, et al.
Published: (2019-04-01)

Extracts from the Leaves of <i>Cissus verticillata</i> Ameliorate High-Fat Diet-Induced Memory Deficits in Mice
by: Woosuk Kim, et al.
Published: (2021-08-01)

Voluntary exercise promotes neurotrophic factor and suppresses apoptosis in hippocampal ischemia
by: Zhixiong Zhang, Rong Li, Xiaoyan Zhang, Yaxuan Wei, Hongbing Ma, Ling Zhu, Rong Yin
Published: (2019-03-01)

Aerobic Exercise Alleviates Ischemia-Induced Memory Impairment by Enhancing Cell Proliferation and Suppressing Neuronal Apoptosis in Hippocampus
by: Tae-Beom Seo, et al.
Published: (2014-12-01)

Brain-derived neurotrophic factor reduces inflammation and hippocampal apoptosis in experimental Streptococcus pneumoniae meningitis
by: Danfeng Xu, et al.
Published: (2017-08-01)

Preventive and Therapeutic Effects of Astaxanthin on Depressive-Like Behaviors in High-Fat Diet and Streptozotocin-Treated Rats
by: Yuting Ke, et al.
Published: (2020-01-01)

Development of natural products as drugs acting on central nervous system
by: Xing-Zu Zhu
Published: (1991-01-01)

Electro-Acupuncture Ameliorated MPTP-Induced Parkinsonism in Mice via TrkB Neurotrophic Signaling
by: Yingke Zhao, et al.
Published: (2019-05-01)

Determining the Optimal Administration Conditions under Which MIF Exerts Neuroprotective Effects by Inducing BDNF Expression and Inhibiting Apoptosis in an in Vitro Stroke Model
by: Chul Jung, et al.
Published: (2021-02-01)

Recombinant human brain-derived neurotrophic factor prevents neuronal apoptosis in a novel in vitro model of subarachnoid hemorrhage
by: Li M, et al.
Published: (2017-04-01)

Exogenous Hydrogen Sulfide Ameliorates Diabetes-Associated Cognitive Decline by Regulating the Mitochondria-Mediated Apoptotic Pathway and IL-23/IL-17 Expression in db/db Mice
by: Shuainan Ma, et al.
Published: (2017-04-01)

The ethanolic extract of Aralia continentalis ameliorates cognitive deficits via modifications of BDNF expression and anti-inflammatory effects in a rat model of post-traumatic stress disorder
by: Bombi Lee, et al.
Published: (2019-01-01)

Repeated transcranial direct current stimulation improves cognitive dysfunction and synaptic plasticity deficit in the prefrontal cortex of streptozotocin-induced diabetic rats
by: Yi-Jen Wu, et al.
Published: (2017-11-01)

TAT-Ngn2 Enhances Cognitive Function Recovery and Regulates Caspase-Dependent and Mitochondrial Apoptotic Pathways After Experimental Stroke
by: Yu Zhao, et al.
Published: (2018-12-01)

Docosahexaenoic acid modulates brain-derived neurotrophic factor via GPR40 in the brain and alleviates diabesity-associated learning and memory deficits in mice
by: Chandan Sona, et al.
Published: (2018-10-01)

Resveratrol, a SIRT1 Activator, Ameliorates MK-801-Induced Cognitive and Motor Impairments in a Neonatal Rat Model of Schizophrenia
by: Juan Niu, et al.
Published: (2020-07-01)

MiR-489-3p inhibits cell proliferation, migration, and invasion, and induces apoptosis, by targeting the BDNF-mediated PI3K/AKT pathway in glioblastoma
by: Zheng Bo, et al.
Published: (2020-05-01)

Neurotrophic Factor Levels in Preterm Infants: A Systematic Review and Meta-Analysis
by: Francieli Cristina Krey, et al.
Published: (2021-04-01)

Dim Light at Night Induced Neurodegeneration and Ameliorative Effect of Curcumin
by: Dhondup Namgyal, et al.
Published: (2020-09-01)

Gene therapy for Huntington's disease
by: Shilpa Ramaswamy, et al.
Published: (2012-11-01)

Expression Analysis of BDNF Gene and BDNF-AS Long Noncoding RNA in Whole Blood Samples of Multiple Sclerosis Patients: Not Always a Negative Correlation between Them
by: Vajiheh Gharzi, et al.
Published: (2018-12-01)

3,5,6,7,8,3′,4′-Heptamethoxyflavone, a Citrus Flavonoid, Ameliorates Corticosterone-Induced Depression-like Behavior and Restores Brain-Derived Neurotrophic Factor Expression, Neurogenesis, and Neuroplasticity in the Hippocampus
by: Atsushi Sawamoto, et al.
Published: (2016-04-01)

Successful Treatment with Atomoxetine of an Adolescent Boy with Attention Deficit/Hyperactivity Disorder, Extreme Obesity, and Reduced Melanocortin 4 Receptor Function
by: Wilfried Pott, et al.
Published: (2013-03-01)