Polysorbates, peroxides, protein aggregation, and immunogenicity – a growing concern
Aggregation can have a number of deleterious effects on biotherapeutics including the loss of efficacy, the induction of unwanted immunogenicity, altered pharmacokinetics, and reduced shelf life. Aggregation is ameliorated by the inclusion of surfactants in biotherapeutics formulations, typically no...
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| Format: | Article |
| Language: | English |
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International Pharmaceutical Excipients Council
2012-06-01
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| Series: | Journal of Excipients and Food Chemicals |
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| Online Access: | https://jefc.scholasticahq.com/article/1108-polysorbates-peroxides-protein-aggregation-and-immunogenicity-a-growing-concern |