Metabolically Activated Adipose Tissue Macrophages Perform Detrimental and Beneficial Functions during Diet-Induced Obesity

Metabolically Activated Adipose Tissue Macrophages Perform Detrimental and Beneficial Functions during Diet-Induced Obesity

During obesity, adipose tissue macrophages (ATMs) adopt a metabolically activated (MMe) phenotype. However, the functions of MMe macrophages are poorly understood. Here, we combine proteomic and functional methods to demonstrate that, in addition to potentiating inflammation, MMe macrophages promote...

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Bibliographic Details
Main Authors: Brittney R. Coats, Kelly Q. Schoenfelt, Valéria C. Barbosa-Lorenzi, Eduard Peris, Chang Cui, Alexandria Hoffman, Guolin Zhou, Sully Fernandez, Lijie Zhai, Ben A. Hall, Abigail S. Haka, Ajay M. Shah, Catherine A. Reardon, Matthew J. Brady, Christopher J. Rhodes, Frederick R. Maxfield, Lev Becker
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Cell Reports
Subjects:
macrophage
obesity
inflammation
insulin resistance
adipocyte
metabolic activation
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717312561

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http://www.sciencedirect.com/science/article/pii/S2211124717312561

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