Genetic Dissection of the Regulatory Mechanisms of Ace2 in the Infected Mouse Lung

Genetic Dissection of the Regulatory Mechanisms of Ace2 in the Infected Mouse Lung

Acute lung injury (ALI) is an important cause of morbidity and mortality after viral infections, including influenza A virus H1N1, SARS-CoV, MERS-CoV, and SARS-CoV-2. The angiotensin I converting enzyme 2 (ACE2) is a key host membrane-bound protein that modulates ALI induced by viral infection, pulm...

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Bibliographic Details
Main Authors: Fuyi Xu, Jun Gao, Silke Bergmann, Amy C. Sims, David G. Ashbrook, Ralph S. Baric, Yan Cui, Colleen B. Jonsson, Kui Li, Robert W. Williams, Klaus Schughart, Lu Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Immunology
Subjects:
H1N1
acute lung injury
BXD family
Ace2
host response
viremia network
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.607314/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.607314/full

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