Fabrication of Intragastric Floating, Controlled Release 3D Printed Theophylline Tablets Using Hot-Melt Extrusion and Fused Deposition Modeling

Fabrication of Intragastric Floating, Controlled Release 3D Printed Theophylline Tablets Using Hot-Melt Extrusion and Fused Deposition Modeling

This work presents a novel approach for producing gastro-retentive floating tablets (GRFT) by coupling hot-melt extrusion (HME) and fused deposition three-dimensional printing (3DP). Filaments containing theophylline (THEO) within a hydroxypropyl cellulose (HPC) matrix were prepared using HME. 3DP t...

Full description

Bibliographic Details
Main Authors: Bhupendra Raj Giri, Eon Soo Song, Jaewook Kwon, Ju-Hyun Lee, Jun-Bom Park, Dong Wuk Kim
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Pharmaceutics
Subjects:
theophylline
hot-melt extrusion
fused deposition modeling 3d printing
gastro-retentive floating system
dissolution kinetics
controlled release
Online Access:https://www.mdpi.com/1999-4923/12/1/77

Internet

https://www.mdpi.com/1999-4923/12/1/77

Similar Items