The Drosophila Small Conductance Calcium-Activated Potassium Channel Negatively Regulates Nociception

Summary: Inhibition of nociceptor activity is important for the prevention of spontaneous pain and hyperalgesia. To identify the critical K+ channels that regulate nociceptor excitability, we performed a forward genetic screen using a Drosophila larval nociception paradigm. Knockdown of three K+ cha...

Full description

Bibliographic Details
Main Authors: Kia C.E. Walcott, Stephanie E. Mauthner, Asako Tsubouchi, Jessica Robertson, W. Daniel Tracey
Format: Article
Language:English
Published: Elsevier 2018-09-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718313743