Development of a Method to Implement Whole-Genome Bisulfite Sequencing of cfDNA from Cancer Patients and a Mouse Tumor Model

Development of a Method to Implement Whole-Genome Bisulfite Sequencing of cfDNA from Cancer Patients and a Mouse Tumor Model

The goal of this study was to develop a method for whole genome cell-free DNA (cfDNA) methylation analysis in humans and mice with the ultimate goal to facilitate the identification of tumor derived DNA methylation changes in the blood. Plasma or serum from patients with pancreatic neuroendocrine tu...

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Bibliographic Details
Main Authors: Elaine C. Maggi, Silvia Gravina, Haiying Cheng, Bilal Piperdi, Ziqiang Yuan, Xiao Dong, Steven K. Libutti, Jan Vijg, Cristina Montagna
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Genetics
Subjects:
cell-free DNA
cfDNA
DNA methylation
non-invasive blood based screening
biomarker
pancreatic cancer
Online Access:http://journal.frontiersin.org/article/10.3389/fgene.2018.00006/full

Internet

http://journal.frontiersin.org/article/10.3389/fgene.2018.00006/full

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