Clinical severity of β-thalassaemia/Hb E disease is associated with differential activities of the calpain-calpastatin proteolytic system.

Clinical severity of β-thalassaemia/Hb E disease is associated with differential activities of the calpain-calpastatin proteolytic system.

Earlier observations in the literature suggest that proteolytic degradation of excess unmatched α-globin chains reduces their accumulation and precipitation in β-thalassaemia erythroid precursor cells and have linked this proteolytic degradation to the activity of calpain protease. The aim of this s...

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Bibliographic Details
Main Authors: Suriyan Sukati, Saovaros Svasti, Roberto Stifanese, Monica Averna, Nantika Panutdaporn, Tipparat Penglong, Edon Melloni, Suthat Fucharoen, Gerd Katzenmeier
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3353910?pdf=render

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http://europepmc.org/articles/PMC3353910?pdf=render

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