Involvement of insulin receptor substrates in cognitive impairment and Alzheimer’s disease

Involvement of insulin receptor substrates in cognitive impairment and Alzheimer’s disease

Type 2 diabetes—associated with impaired insulin/insulin-like growth factor-1 (IGF1) signaling (IIS)—is a risk factor for cognitive impairment and dementia including Alzheimer’s disease (AD). The insulin receptor substrate (IRS) proteins are major components of IIS, which transmit upstream signals v...

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Bibliographic Details
Main Authors: Daisuke Tanokashira, Wataru Fukuokaya, Akiko Taguchi
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2019-01-01
Series:Neural Regeneration Research
Subjects:
type 2 diabetes; insulin/insulin-like growth factor-1; insulin receptor substrate; Alzheimer′s disease; aging; serine phosphorylation; metformin; neuroprotective effects; high-fat-diet
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=8;spage=1330;epage=1334;aulast=Tanokashira

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=8;spage=1330;epage=1334;aulast=Tanokashira

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