Diet and cholesterolemia: VII. Effects of methionine, ethionine, and p-fluorophenylalanine*

The concentration of serum cholesterol in rats fed a diet containing cholesterol, cholic acid, and hydrogenated coconut oil was reduced when ethionine was included in the diet. This effect was not due to depressed intake of food or of cholesterol. The addition of equal amounts of ethionine and methi...

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Main Authors:	John C. Seidel, A.E. Harper
Format:	Article
Language:	English
Published:	Elsevier 1963-01-01
Series:	Journal of Lipid Research
Online Access:	http://www.sciencedirect.com/science/article/pii/S0022227520403694

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spelling	doaj-9d8339ad8e32463fbd48b388a7f5e3f32021-04-23T06:12:49ZengElsevierJournal of Lipid Research0022-22751963-01-01417580Diet and cholesterolemia: VII. Effects of methionine, ethionine, and p-fluorophenylalanine*John C. Seidel0A.E. Harper1Department of Biochemistry, University of Wisconsin, Madison 6, WisconsinDepartment of Biochemistry, University of Wisconsin, Madison 6, WisconsinThe concentration of serum cholesterol in rats fed a diet containing cholesterol, cholic acid, and hydrogenated coconut oil was reduced when ethionine was included in the diet. This effect was not due to depressed intake of food or of cholesterol. The addition of equal amounts of ethionine and methionine to this diet maintained serum cholesterol at levels significantly below those of rats supplemented with ethionine alone. This addition of methionine also very largely prevented the depression of growth caused by ethionine. Administration of p-fluorophenylalanine lowered the concentration of cholesterol in the serum but β-2-thienylalanine had little effect.http://www.sciencedirect.com/science/article/pii/S0022227520403694
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	John C. Seidel A.E. Harper
spellingShingle	John C. Seidel A.E. Harper Diet and cholesterolemia: VII. Effects of methionine, ethionine, and p-fluorophenylalanine* Journal of Lipid Research
author_facet	John C. Seidel A.E. Harper
author_sort	John C. Seidel
title	Diet and cholesterolemia: VII. Effects of methionine, ethionine, and p-fluorophenylalanine*
title_short	Diet and cholesterolemia: VII. Effects of methionine, ethionine, and p-fluorophenylalanine*
title_full	Diet and cholesterolemia: VII. Effects of methionine, ethionine, and p-fluorophenylalanine*
title_fullStr	Diet and cholesterolemia: VII. Effects of methionine, ethionine, and p-fluorophenylalanine*
title_full_unstemmed	Diet and cholesterolemia: VII. Effects of methionine, ethionine, and p-fluorophenylalanine*
title_sort	diet and cholesterolemia: vii. effects of methionine, ethionine, and p-fluorophenylalanine*
publisher	Elsevier
series	Journal of Lipid Research
issn	0022-2275
publishDate	1963-01-01
description	The concentration of serum cholesterol in rats fed a diet containing cholesterol, cholic acid, and hydrogenated coconut oil was reduced when ethionine was included in the diet. This effect was not due to depressed intake of food or of cholesterol. The addition of equal amounts of ethionine and methionine to this diet maintained serum cholesterol at levels significantly below those of rats supplemented with ethionine alone. This addition of methionine also very largely prevented the depression of growth caused by ethionine. Administration of p-fluorophenylalanine lowered the concentration of cholesterol in the serum but β-2-thienylalanine had little effect.
url	http://www.sciencedirect.com/science/article/pii/S0022227520403694
work_keys_str_mv	AT johncseidel dietandcholesterolemiaviieffectsofmethionineethionineandpfluorophenylalanine AT aeharper dietandcholesterolemiaviieffectsofmethionineethionineandpfluorophenylalanine
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Diet and cholesterolemia: VII. Effects of methionine, ethionine, and p-fluorophenylalanine*

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