Epithelial cells supply Sonic Hedgehog to the perinatal dentate gyrus via transport by platelets

Dentate neural stem cells produce neurons throughout life in mammals. Sonic hedgehog (Shh) is critical for maintenance of these cells; however, the perinatal source of Shh is enigmatic. In the present study, we examined the role of Shh expressed by hair follicles (HFs) that expand perinatally in tem...

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Bibliographic Details
Main Authors: Youngshik Choe, Trung Huynh, Samuel J Pleasure
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-10-01
Series:eLife
Subjects:
Shh
Online Access:https://elifesciences.org/articles/07834