Preclinical and Clinical Evidence for a Distinct Regulation of Mu Opioid and Type 1 Cannabinoid Receptor Genes Expression in Obesity

Preclinical and Clinical Evidence for a Distinct Regulation of Mu Opioid and Type 1 Cannabinoid Receptor Genes Expression in Obesity

Among endogenous signaling networks involved in both rewarding and homeostatic mechanisms of obesity, a relevant role is played by the endocannabinoid (ECS) and the opioid (EOS) systems. We here studied the transcriptional regulation of ECS and EOS genes in the hypothalamus of Diet-induced obesity r...

Full description

Bibliographic Details
Main Authors: Mariangela Pucci, Maria Vittoria Micioni Di Bonaventura, Valeria Vezzoli, Elizabeta Zaplatic, Marcella Massimini, Stefania Mai, Alessandro Sartorio, Massimo Scacchi, Luca Persani, Mauro Maccarrone, Carlo Cifani, Claudio D’Addario
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Genetics
Subjects:
obesity
endocannabinoid system
opioid system
DNA methylation
biomarker
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00523/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2019.00523/full

Similar Items