Optogenetic activation of 5-HT neurons in the dorsal raphe suppresses seizure-induced respiratory arrest and produces anticonvulsant effect in the DBA/1 mouse SUDEP model

Optogenetic activation of 5-HT neurons in the dorsal raphe suppresses seizure-induced respiratory arrest and produces anticonvulsant effect in the DBA/1 mouse SUDEP model

Sudden unexpected death in epilepsy (SUDEP) is a devastating epilepsy complication. Seizure-induced respiratory arrest (S-IRA) occurs in many witnessed SUDEP patients and animal models as an initiating event leading to death. Thus, understanding the mechanisms underlying S-IRA will advance the devel...

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Bibliographic Details
Main Authors: Honghai Zhang, Haiting Zhao, Chang Zeng, Christa Van Dort, Carl L. Faingold, Norman E. Taylor, Ken Solt, Hua-Jun Feng
Format: Article
Language:English
Published: Elsevier 2018-02-01
Series:Neurobiology of Disease
Subjects:
Photostimulation
Serotonin
5-Hydroxytryptophan
Ondansetron
Generalized seizures
Pentylenetetrazole
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996117302553

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http://www.sciencedirect.com/science/article/pii/S0969996117302553

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