Alteration of retinal rod outer segment membrane fluidity in a rat model of Smith-Lemli-Opitz syndrome*

Alteration of retinal rod outer segment membrane fluidity in a rat model of Smith-Lemli-Opitz syndrome*

Smith-Lemli-Opitz syndrome (SLOS) is caused by an inherited defect in the last step in cholesterol (Chol) biosynthesis, leading to abnormal accumulation of 7-dehydrocholesterol and decreased Chol levels. Progressive retinal degeneration occurs in an animal model of SLOS, induced by treating rats wit...

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Bibliographic Details
Main Authors: Kathleen Boesze-Battaglia, Monika Damek-Poprawa, Drake C. Mitchell, Laura Greeley, Richard S. Brush, Robert E. Anderson, Michael J. Richards, Steven J. Fliesler
Format: Article
Language:English
Published: Elsevier 2008-07-01
Series:Journal of Lipid Research
Subjects:
fluorescence polarization
cis-parinaric acid
diphenylhexatriene
fatty acid
retina
AY9944
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520347209

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http://www.sciencedirect.com/science/article/pii/S0022227520347209

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