Apolipoprotein E4 enhances brain inflammation by modulation of the NF-κB signaling cascade

Apolipoprotein E4 enhances brain inflammation by modulation of the NF-κB signaling cascade

Apolipoprotein E4 (apoE4), the major genetic risk factor of Alzheimer's disease (AD), is associated with enhanced brain inflammation. Genome-wide gene expression profiling was employed to study the effects of apoE genotype on hippocampal gene expression in LPS-treated mice, transgenic for eithe...

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Bibliographic Details
Main Authors: Gal Ophir, Ninette Amariglio, Jasmine Jacob-Hirsch, Ran Elkon, Gideon Rechavi, Daniel M. Michaelson
Format: Article
Language:English
Published: Elsevier 2005-12-01
Series:Neurobiology of Disease
Subjects:
Apolipoprotein E4
Inflammation
Alzheimer's disease
Microarray
NF-κB
LPS
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996105001403

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http://www.sciencedirect.com/science/article/pii/S0969996105001403

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