Reactivation of a developmental Bmp2 signaling center is required for therapeutic control of the murine periosteal niche

Reactivation of a developmental Bmp2 signaling center is required for therapeutic control of the murine periosteal niche

Two decades after signals controlling bone length were discovered, the endogenous ligands determining bone width remain unknown. We show that postnatal establishment of normal bone width in mice, as mediated by bone-forming activity of the periosteum, requires BMP signaling at the innermost layer of...

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Bibliographic Details
Main Authors: Valerie S Salazar, Luciane P Capelo, Claudio Cantù, Dario Zimmerli, Nehal Gosalia, Steven Pregizer, Karen Cox, Satoshi Ohte, Marina Feigenson, Laura Gamer, Jeffry S Nyman, David J Carey, Aris Economides, Konrad Basler, Vicki Rosen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-02-01
Series:eLife
Subjects:
periosteum
BMP
WNT
fracture
bone
skeletal
Online Access:https://elifesciences.org/articles/42386

Internet

https://elifesciences.org/articles/42386

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