Sporadic Creutzfeldt-Jakob disease prion infection of human cerebral organoids

Sporadic Creutzfeldt-Jakob disease prion infection of human cerebral organoids

Abstract For the transmissible, neurogenerative family of prion diseases, few human models of infection exist and none represent structured neuronal tissue. Human cerebral organoids are self-organizing, three-dimensional brain tissues that can be grown from induced pluripotent stem cells. Organoids...

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Bibliographic Details
Main Authors: Bradley R. Groveman, Simote T. Foliaki, Christina D. Orru, Gianluigi Zanusso, James A. Carroll, Brent Race, Cathryn L. Haigh
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Acta Neuropathologica Communications
Subjects:
Prion
CJD
Human cerebral organoid
Induced pluripotent stem cells
RT-QuIC
Online Access:http://link.springer.com/article/10.1186/s40478-019-0742-2

Internet

http://link.springer.com/article/10.1186/s40478-019-0742-2

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