Human blood serum can donor-specifically antagonize effects of EGFR-targeted drugs on squamous carcinoma cell growth

Human blood serum can donor-specifically antagonize effects of EGFR-targeted drugs on squamous carcinoma cell growth

Many patients fail to respond to EGFR-targeted therapeutics, and personalized diagnostics is needed to identify putative responders. We investigated 1630 colorectal and lung squamous carcinomas and 1357 normal lung and colon samples and observed huge variation in EGFR pathway activation in both canc...

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Bibliographic Details
Main Authors: Dmitry Kamashev, Maksim Sorokin, Irina Kochergina, Aleksey Drobyshev, Uliana Vladimirova, Marianna Zolotovskaia, Igor Vorotnikov, Nina Shaban, Mikhail Raevskiy, Denis Kuzmin, Anton Buzdin
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Heliyon
Subjects:
Lung cancer
Colorectal cancer
EGFR
HER-targeted therapy
Human blood serum
Cetuximab
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844021004990

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http://www.sciencedirect.com/science/article/pii/S2405844021004990

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