Mechanisms by which Human Cells Bypass Damaged Bases during DNA Replication after Ultraviolet Irradiation
The replication of damaged DNA involves cascading mechanisms of increasing complexity but decreasing accuracy. The most accurate mechanism uses low-fidelity DNA polymerases, Pol H and Pol I, which have active sites sufficiently large to accommodate a pyrimidine dimer. Replicative bypass of DNA damag...
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| Format: | Article |
| Language: | English |
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Hindawi Limited
2002-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2002.348 |