Conditional Deletion of PGC-1α Results in Energetic and Functional Defects in NK Cells

Conditional Deletion of PGC-1α Results in Energetic and Functional Defects in NK Cells

Summary: During an immune response, natural killer (NK) cells activate specific metabolic pathways to meet the increased energetic and biosynthetic demands associated with effector functions. Here, we found in vivo activation of NK cells during Listeria monocytogenes infection-augmented transcriptio...

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Bibliographic Details
Main Authors: Zachary J. Gerbec, Elaheh Hashemi, Arash Nanbakhsh, Sandra Holzhauer, Chao Yang, Ao Mei, Shirng-Wern Tsaih, Angela Lemke, Michael J. Flister, Matthew J. Riese, Monica S. Thakar, Subramaniam Malarkannan
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:iScience
Subjects:
Biological Sciences
Cellular Physiology
Immunology
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220306465

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http://www.sciencedirect.com/science/article/pii/S2589004220306465

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