Knockdown of N-Acetylglucosaminyltransferase-II Reduces Matrix Metalloproteinase 2 Activity and Suppresses Tumorigenicity in Neuroblastoma Cell Line

Knockdown of N-Acetylglucosaminyltransferase-II Reduces Matrix Metalloproteinase 2 Activity and Suppresses Tumorigenicity in Neuroblastoma Cell Line

Neuroblastoma (NB) development and progression are accompanied by changes in N-glycans attached to proteins. Here, we investigated the role of N-acetylglucosaminyltransferase-II (GnTII, <i>MGAT2</i>) protein substrates in neuroblastoma (NB) cells. <i>MGAT2</i> was silenced in...

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Bibliographic Details
Main Authors: M. Kristen Hall, Austin A. Whitman, Douglas A. Weidner, Ruth A. Schwalbe
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Biology
Subjects:
glycans
neuroblastoma
cell invasiveness
cell proliferation
MMP-2
EGFR
Online Access:https://www.mdpi.com/2079-7737/9/4/71

Internet

https://www.mdpi.com/2079-7737/9/4/71

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