An atlas of altered expression of deubiquitinating enzymes in human cancer.

BACKGROUND: Deubiquitinating enzymes (DUBs) are proteases that process ubiquitin (Ub) or ubiquitin-like gene products, remodel polyubiquitin(-like) chains on target proteins, and counteract protein ubiquitination exerted by E3 ubiquitin-ligases. A wealth of studies has established the relevance of D...

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Main Authors: Chiara Luise, Maria Capra, Maddalena Donzelli, Giovanni Mazzarol, Maria Giovanna Jodice, Paolo Nuciforo, Giuseppe Viale, Pier Paolo Di Fiore, Stefano Confalonieri
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3026797?pdf=render