Sphingosine Kinase 1 Regulates the Survival of Breast Cancer Stem Cells and Non-stem Breast Cancer Cells by Suppression of STAT1

Sphingosine Kinase 1 Regulates the Survival of Breast Cancer Stem Cells and Non-stem Breast Cancer Cells by Suppression of STAT1

Cancer stem cells (CSCs) represent rare tumor cell populations capable of self-renewal, differentiation, and tumor initiation and are highly resistant to chemotherapy and radiotherapy. Thus, therapeutic approaches that can effectively target CSCs and tumor cells could be the key to efficient tumor t...

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Bibliographic Details
Main Authors: Ling-Wei Hii, Felicia Fei-Lei Chung, Chun Wai Mai, Zong Yang Yee, Hong Hao Chan, Vijay Joseph Raja, Noah Elias Dephoure, Nigel J. Pyne, Susan Pyne, Chee-Onn Leong
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cells
Subjects:
cancer stem cells
sphingosine kinase
STAT1
mammospheres
drug synergism
sphingolipids
Online Access:https://www.mdpi.com/2073-4409/9/4/886

Internet

https://www.mdpi.com/2073-4409/9/4/886

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