A first order phase transition mechanism underlies protein aggregation in mammalian cells

The formation of misfolded protein aggregates is a hallmark of neurodegenerative diseases. The aggregate formation process exhibits an initial lag phase when precursor clusters spontaneously assemble. However, most experimental assays are blind to this lag phase. We develop a quantitative assay base...

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Bibliographic Details
Main Authors: Arjun Narayanan, Anatoli Meriin, J Owen Andrews, Jan-Hendrik Spille, Michael Y Sherman, Ibrahim I Cisse
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-02-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/39695