Combining a CD20 chimeric antigen receptor and an inducible caspase 9 suicide switch to improve the efficacy and safety of T cell adoptive immunotherapy for lymphoma.

Combining a CD20 chimeric antigen receptor and an inducible caspase 9 suicide switch to improve the efficacy and safety of T cell adoptive immunotherapy for lymphoma.

Modification of T cells with chimeric antigen receptors (CAR) has emerged as a promising treatment modality for human malignancies. Integration of co-stimulatory domains into CARs can augment the activation and function of genetically targeted T cells against tumors. However, the potential for inser...

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Bibliographic Details
Main Authors: Lihua E Budde, Carolina Berger, Yukang Lin, Jinjuan Wang, Xubin Lin, Shani E Frayo, Shaunda A Brouns, David M Spencer, Brian G Till, Michael C Jensen, Stanley R Riddell, Oliver W Press
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3866194?pdf=render

Internet

http://europepmc.org/articles/PMC3866194?pdf=render

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