Tetraspanin 1 promotes epithelial-to-mesenchymal transition and metastasis of cholangiocarcinoma via PI3K/AKT signaling

Tetraspanin 1 promotes epithelial-to-mesenchymal transition and metastasis of cholangiocarcinoma via PI3K/AKT signaling

Abstract Background Numerous studies have demonstrated that tetraspanin 1 (TSPAN1), a transmembrane protein, functions as an oncoprotein in many cancer types. However, its role and underlying molecular mechanism in cholangiocarcinoma (CCA) progression remain unclear. Methods In the present study, th...

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Bibliographic Details
Main Authors: Yan Wang, Yingjian Liang, Guangchao Yang, Yaliang Lan, Jihua Han, Jiabei Wang, Dalong Yin, Ruipeng Song, Tongsen Zheng, Shugeng Zhang, Shangha Pan, Xirui Liu, Mingxi Zhu, Yao Liu, Yifeng Cui, Fanzheng Meng, Bo Zhang, Shuhang Liang, Hongrui Guo, Yufeng Liu, Md Khaled Hassan, Lianxin Liu
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Cholangiocarcinoma
Tetraspanin 1
Epithelial-to-mesenchymal transition
MicroRNA-194-5p
Integrin α6β1
Online Access:http://link.springer.com/article/10.1186/s13046-018-0969-y

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http://link.springer.com/article/10.1186/s13046-018-0969-y

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