Major CD4 T-Cell Depletion and Immune Senescence in a Patient with Chronic Granulomatous Disease

Major CD4 T-Cell Depletion and Immune Senescence in a Patient with Chronic Granulomatous Disease

Chronic granulomatous disease (CGD) results from primary defects in phagocytic reactive oxygen species (ROS) production. T-cell evaluation is usually neglected during patients’ follow-up, although T-cell depletion has been reported in CGD through unknown mechanisms. We describe here a 36-year-old pa...

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Bibliographic Details
Main Authors: Adriana S. Albuquerque, Susana M. Fernandes, Rita Tendeiro, Rémi Cheynier, Margarida Lucas, Susana L. Silva, Rui M. M. Victorino, Ana E. Sousa
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Immunology
Subjects:
primary immunodeficiency
chronic granulomatous disease
genetic phagocytic defect
reactive oxygen species
CD4 T-cell lymphopenia
immune senescence
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00543/full

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http://journal.frontiersin.org/article/10.3389/fimmu.2017.00543/full

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