Antitumor activity of a 5T4 targeting antibody drug conjugate with a novel payload derived from MMAF via C‐Lock linker

Antitumor activity of a 5T4 targeting antibody drug conjugate with a novel payload derived from MMAF via C‐Lock linker

Abstract Antibody‐drug conjugates (ADCs) belong to a promising class of biopharmaceuticals in which target‐killing of tumor cells was achieved by marrying the potency of the cytotoxic payload with the tumor specificity of the antibody. Here we developed a novel ADC (ZV0508) that targets 5T4 oncofeta...

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Bibliographic Details
Main Authors: Baoying Shi, Min Wu, Zhaohui Li, Zhangming Xie, Xiaoyue Wei, Jiansheng Fan, Yingchun Xu, Ding Ding, Sajid Hamid Akash, Shuqing Chen, Sheldon Cao
Format: Article
Language:English
Published: Wiley 2019-04-01
Series:Cancer Medicine
Subjects:
antibody drug conjugate
antitumor activity
C‐Lock linker
MMAF analogue
ZV0508
Online Access:https://doi.org/10.1002/cam4.2066

Internet

https://doi.org/10.1002/cam4.2066

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