The Role of the Immunological Synapse in Differential Effects of APC Subsets in Alloimmunization to Fresh, Non-stored RBCs

The Role of the Immunological Synapse in Differential Effects of APC Subsets in Alloimmunization to Fresh, Non-stored RBCs

Background: Each year, over 5 million red blood cell (RBC) transfusions are administered to patients in the USA. Despite the therapeutic benefits of RBC transfusions, there are associated risks. RBC-specific alloantibodies may form in response to antigenic differences between RBC donors and recipien...

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Bibliographic Details
Main Authors: Amanda L. Richards, Kathryn Sheldon, Xiaoping Wu, David R. Gruber, Krystalyn E. Hudson
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
Red blood cells (RBC)
transfusion
alloimmunization
inflammation
alloantibodies
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02200/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02200/full

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