Elevated in vivo levels of a single transcription factor directly convert satellite glia into oligodendrocyte-like cells.
Oligodendrocytes are the myelinating glia of the central nervous system and ensure rapid saltatory conduction. Shortage or loss of these cells leads to severe malfunctions as observed in human leukodystrophies and multiple sclerosis, and their replenishment by reprogramming or cell conversion strate...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-02-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC4334169?pdf=render |