Quinolinecarboxamides Inhibit the Replication of the Bovine Viral Diarrhea Virus by Targeting a Hot Spot for the Inhibition of Pestivirus Replication in the RNA-Dependent RNA Polymerase

Quinolinecarboxamides Inhibit the Replication of the Bovine Viral Diarrhea Virus by Targeting a Hot Spot for the Inhibition of Pestivirus Replication in the RNA-Dependent RNA Polymerase

The bovine viral diarrhea virus (BVDV), a pestivirus from the family of <i>Flaviviridae</i> is ubiquitous and causes a range of clinical manifestations in livestock, mainly cattle. Two quinolinecarboxamide analogues were identified in a CPE-based screening effort, as selective inhibitors...

Full description

Bibliographic Details
Main Authors: Simone Musiu, Yunierkis Perez Castillo, Alexandra Muigg, Gerhard Pürstinger, Pieter Leyssen, Mathy Froeyen, Johan Neyts, Jan Paeshuyse
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Molecules
Subjects:
bovine viral diarrhea virus
rna-dependent rna polymerase
substituted quinolinecarboxamide inhibitors
Online Access:https://www.mdpi.com/1420-3049/25/6/1283

Internet

https://www.mdpi.com/1420-3049/25/6/1283

Similar Items