Negatively charged phospholipids stimulate factor XI activation by thrombin

Negatively charged phospholipids stimulate factor XI activation by thrombin

Introduction: Coagulation factor XI (FXI) is the zymogen of the serine-protease FXIa, which contributes to thrombin formation by activating factor IX. FXI can be activated by factor XIIa or thrombin, but thrombin-catalysed FXI activation is highly inefficient, unless stimulated by polyanions such as...

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Bibliographic Details
Main Authors: Farida Omarova, Jan Rosing, Rogier M. Bertina, Elisabetta Castoldi
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Thrombosis Update
Subjects:
Factor XI
Thrombin
Phospholipids
Exosites
Ionic strength
Online Access:http://www.sciencedirect.com/science/article/pii/S2666572720300225

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http://www.sciencedirect.com/science/article/pii/S2666572720300225

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