Temporal perturbation of ERK dynamics reveals network architecture of FGF2/MAPK signaling

Temporal perturbation of ERK dynamics reveals network architecture of FGF2/MAPK signaling

Abstract Stimulation of PC‐12 cells with epidermal (EGF) versus nerve (NGF) growth factors (GFs) biases the distribution between transient and sustained single‐cell ERK activity states, and between proliferation and differentiation fates within a cell population. We report that fibroblast GF (FGF2)...

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Bibliographic Details
Main Authors: Yannick Blum, Jan Mikelson, Maciej Dobrzyński, Hyunryul Ryu, Marc‐Antoine Jacques, Noo Li Jeon, Mustafa Khammash, Olivier Pertz
Format: Article
Language:English
Published: Wiley 2019-11-01
Series:Molecular Systems Biology
Subjects:
cell fate determination
ERK signaling dynamics
mechanistic modeling
microfluidics
parameter estimation
Online Access:https://doi.org/10.15252/msb.20198947

Internet

https://doi.org/10.15252/msb.20198947

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