A Retinoic Acid-Hedgehog Cascade Coordinates Mesoderm-Inducing Signals and Endoderm Competence during Lung Specification

A Retinoic Acid-Hedgehog Cascade Coordinates Mesoderm-Inducing Signals and Endoderm Competence during Lung Specification

Organogenesis of the trachea and lungs requires a complex series of mesoderm-endoderm interactions mediated by WNT, BMP, retinoic acid (RA), and hedgehog (Hh), but how these pathways interact in a gene regulatory network is less clear. Using Xenopus embryology, mouse genetics, and human ES cell cult...

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Bibliographic Details
Main Authors: Scott A. Rankin, Lu Han, Kyle W. McCracken, Alan P. Kenny, Christopher T. Anglin, Emily A. Grigg, Calyn M. Crawford, James M. Wells, John M. Shannon, Aaron M. Zorn
Format: Article
Language:English
Published: Elsevier 2016-06-01
Series:Cell Reports
Subjects:
retinoic acid
Hedgehog
Wnt
Bmp
Nkx2-1
lung development
organogenesis
Xenopus
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716306581

Internet

http://www.sciencedirect.com/science/article/pii/S2211124716306581

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