Remodeling of the Lymph Node High Endothelial Venules Reflects Tumor Invasiveness in Breast Cancer and is Associated with Dysregulation of Perivascular Stromal Cells

Remodeling of the Lymph Node High Endothelial Venules Reflects Tumor Invasiveness in Breast Cancer and is Associated with Dysregulation of Perivascular Stromal Cells

The tumor-draining lymph nodes (TDLNs) are primary sites for induction of tumor immunity. They are also common sites of metastasis, suggesting that tumor-induced mechanisms can subvert anti-tumor immune responses and promote metastatic seeding. The high endothelial venules (HEVs) together with CCL21...

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Bibliographic Details
Main Authors: Tove Bekkhus, Teemu Martikainen, Anna Olofsson, Mathias Franzén Boger, Daniel Vasiliu Bacovia, Fredrik Wärnberg, Maria H. Ulvmar
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cancers
Subjects:
lymph node
pre-metastatic changes
CCL21
high endothelial venule (HEV)
T-lymphocytes
heparan sulfate
Online Access:https://www.mdpi.com/2072-6694/13/2/211

Internet

https://www.mdpi.com/2072-6694/13/2/211

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