An optimized targeted Next-Generation Sequencing approach for sensitive detection of single nucleotide variants

An optimized targeted Next-Generation Sequencing approach for sensitive detection of single nucleotide variants

Monitoring of minimal residual disease (MRD) has become an important clinical aspect for early relapse detection during follow-up care after cancer treatment. Still, the sensitive detection of single base pair point mutations via Next-Generation Sequencing (NGS) is hampered mainly due to high substi...

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Bibliographic Details
Main Authors: S. Stasik, C. Schuster, C. Ortlepp, U. Platzbecker, M. Bornhäuser, J. Schetelig, G. Ehninger, G. Folprecht, C. Thiede
Format: Article
Language:English
Published: Elsevier 2018-05-01
Series:Biomolecular Detection and Quantification
Online Access:http://www.sciencedirect.com/science/article/pii/S2214753517302115

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http://www.sciencedirect.com/science/article/pii/S2214753517302115

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