P2X7 receptors exert a permissive effect on the activation of presynaptic AMPA receptors in rat trigeminal caudal nucleus glutamatergic nerve terminals

Abstract Background Purine receptors play roles in peripheral and central sensitization and are associated with migraine headache. We investigated the possibility that ATP plays a permissive role in the activation of AMPA receptors thus inducing Glu release from nerve terminals isolated from the rat...

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Bibliographic Details
Main Authors: Diego Currò, Pierluigi Navarra, Irene Samengo, Maria Martire
Format: Article
Language:English
Published: BMC 2020-07-01
Series:The Journal of Headache and Pain
Subjects:
Online Access:http://link.springer.com/article/10.1186/s10194-020-01153-y