Hydrogen sulfide donor GYY4137 suppresses proliferation of human colorectal cancer Caco-2 cells by inducing both cell cycle arrest and cell death
Conflicting data regarding the ability of hydrogen sulfide (H2S), which reaches high levels in the large intestine owing to biosynthesis in the intestinal cells and intestinal bacteria, to promote or inhibit colorectal cancer cell proliferation have been reported recently. In the present study, the...
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Elsevier
2019-08-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844019359043 |
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doaj-9c0ff6d1223c41af9d552ee67330468a2020-11-25T02:54:55ZengElsevierHeliyon2405-84402019-08-0158e02244Hydrogen sulfide donor GYY4137 suppresses proliferation of human colorectal cancer Caco-2 cells by inducing both cell cycle arrest and cell deathSatoru Sakuma0Saaya Minamino1Maya Takase2Yoshitaka Ishiyama3Hiroyuki Hosokura4Tetsuya Kohda5Yukino Ikeda6Yohko Fujimoto7Department of Physiological Chemistry, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, JapanDepartment of Physiological Chemistry, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, JapanDepartment of Physiological Chemistry, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, JapanDepartment of Physiological Chemistry, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, JapanDepartment of Physiological Chemistry, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, JapanDepartment of Physiological Chemistry, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, JapanDepartment of Physiological Chemistry, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, JapanCorresponding author.; Department of Physiological Chemistry, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, JapanConflicting data regarding the ability of hydrogen sulfide (H2S), which reaches high levels in the large intestine owing to biosynthesis in the intestinal cells and intestinal bacteria, to promote or inhibit colorectal cancer cell proliferation have been reported recently. In the present study, the effect of H2S on the proliferation of the human colorectal cancer cell line Caco-2 was examined by using the H2S donor GYY4137. At concentrations of 0.5 mM and 1.0 mM, GYY4137 significantly inhibited Caco-2 cell viability. Cell cycle analysis, and apoptosis and necrosis detection revealed that the anti-proliferative effect of GYY4137 was partially attributable to the induction of S-G2/M cell cycle arrest, apoptosis and necrosis. These results suggest that H2S has the potential to suppress human colorectal cancer cell proliferation by influencing both cell cycle and cell death.http://www.sciencedirect.com/science/article/pii/S2405844019359043Food chemistryNutritionEnvironmental toxicologyBiochemistryMolecular biologyCancer research |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Satoru Sakuma Saaya Minamino Maya Takase Yoshitaka Ishiyama Hiroyuki Hosokura Tetsuya Kohda Yukino Ikeda Yohko Fujimoto |
| spellingShingle |
Satoru Sakuma Saaya Minamino Maya Takase Yoshitaka Ishiyama Hiroyuki Hosokura Tetsuya Kohda Yukino Ikeda Yohko Fujimoto Hydrogen sulfide donor GYY4137 suppresses proliferation of human colorectal cancer Caco-2 cells by inducing both cell cycle arrest and cell death Heliyon Food chemistry Nutrition Environmental toxicology Biochemistry Molecular biology Cancer research |
| author_facet |
Satoru Sakuma Saaya Minamino Maya Takase Yoshitaka Ishiyama Hiroyuki Hosokura Tetsuya Kohda Yukino Ikeda Yohko Fujimoto |
| author_sort |
Satoru Sakuma |
| title |
Hydrogen sulfide donor GYY4137 suppresses proliferation of human colorectal cancer Caco-2 cells by inducing both cell cycle arrest and cell death |
| title_short |
Hydrogen sulfide donor GYY4137 suppresses proliferation of human colorectal cancer Caco-2 cells by inducing both cell cycle arrest and cell death |
| title_full |
Hydrogen sulfide donor GYY4137 suppresses proliferation of human colorectal cancer Caco-2 cells by inducing both cell cycle arrest and cell death |
| title_fullStr |
Hydrogen sulfide donor GYY4137 suppresses proliferation of human colorectal cancer Caco-2 cells by inducing both cell cycle arrest and cell death |
| title_full_unstemmed |
Hydrogen sulfide donor GYY4137 suppresses proliferation of human colorectal cancer Caco-2 cells by inducing both cell cycle arrest and cell death |
| title_sort |
hydrogen sulfide donor gyy4137 suppresses proliferation of human colorectal cancer caco-2 cells by inducing both cell cycle arrest and cell death |
| publisher |
Elsevier |
| series |
Heliyon |
| issn |
2405-8440 |
| publishDate |
2019-08-01 |
| description |
Conflicting data regarding the ability of hydrogen sulfide (H2S), which reaches high levels in the large intestine owing to biosynthesis in the intestinal cells and intestinal bacteria, to promote or inhibit colorectal cancer cell proliferation have been reported recently. In the present study, the effect of H2S on the proliferation of the human colorectal cancer cell line Caco-2 was examined by using the H2S donor GYY4137. At concentrations of 0.5 mM and 1.0 mM, GYY4137 significantly inhibited Caco-2 cell viability. Cell cycle analysis, and apoptosis and necrosis detection revealed that the anti-proliferative effect of GYY4137 was partially attributable to the induction of S-G2/M cell cycle arrest, apoptosis and necrosis. These results suggest that H2S has the potential to suppress human colorectal cancer cell proliferation by influencing both cell cycle and cell death. |
| topic |
Food chemistry Nutrition Environmental toxicology Biochemistry Molecular biology Cancer research |
| url |
http://www.sciencedirect.com/science/article/pii/S2405844019359043 |
| work_keys_str_mv |
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| _version_ |
1724719071996411904 |