Hydrogen sulfide donor GYY4137 suppresses proliferation of human colorectal cancer Caco-2 cells by inducing both cell cycle arrest and cell death

Conflicting data regarding the ability of hydrogen sulfide (H2S), which reaches high levels in the large intestine owing to biosynthesis in the intestinal cells and intestinal bacteria, to promote or inhibit colorectal cancer cell proliferation have been reported recently. In the present study, the...

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Bibliographic Details
Main Authors: Satoru Sakuma, Saaya Minamino, Maya Takase, Yoshitaka Ishiyama, Hiroyuki Hosokura, Tetsuya Kohda, Yukino Ikeda, Yohko Fujimoto
Format: Article
Language:English
Published: Elsevier 2019-08-01
Series:Heliyon
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844019359043