Systems-based identification of temporal processing pathways during bone cell mechanotransduction.

Bone has long been established to be a highly mechanosensitive tissue. When subjected to mechanical loading, bone exhibits profoundly different anabolic responses depending on the temporal pattern in which the stimulus is applied. This phenomenon has been termed temporal processing, and involves com...

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Bibliographic Details
Main Authors: Leah E Worton, Brandon J Ausk, Leah M Downey, Steven D Bain, Edith M Gardiner, Sundar Srinivasan, Ted S Gross, Ronald Y Kwon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3770665?pdf=render