Arginylglycylaspartic Acid-Surface-Functionalized Doxorubicin-Loaded Lipid-Core Nanocapsules as a Strategy to Target Alpha(V) Beta(3) Integrin Expressed on Tumor Cells

Arginylglycylaspartic Acid-Surface-Functionalized Doxorubicin-Loaded Lipid-Core Nanocapsules as a Strategy to Target Alpha(V) Beta(3) Integrin Expressed on Tumor Cells

Doxorubicin (Dox) clinical use is limited by dose-related cardiomyopathy, becoming more prevalent with increasing cumulative doses. Previously, we developed Dox-loaded lipid-core nanocapsules (Dox-LNC) and, in this study, we hypothesized that self-assembling and interfacial reactions could be used t...

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Bibliographic Details
Main Authors: Michelli B. Antonow, Camila Franco, Willian Prado, Aline Beckenkamp, Gustavo P. Silveira, Andréia Buffon, Sílvia S. Guterres, Adriana R. Pohlmann
Format: Article
Language:English
Published: MDPI AG 2017-12-01
Series:Nanomaterials
Subjects:
lipid-core nanocapsules
cancer
RGD
Doxorubicin
active drug targeting
surface-functionalization
Online Access:https://www.mdpi.com/2079-4991/8/1/2

Internet

https://www.mdpi.com/2079-4991/8/1/2

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