Aberrant Expression of High Mobility Group Box Protein 1 in the Idiopathic Inflammatory Myopathies

Aberrant Expression of High Mobility Group Box Protein 1 in the Idiopathic Inflammatory Myopathies

IntroductionHigh Mobility Group Box Protein 1 (HMGB1) is a DNA-binding protein that exerts inflammatory or pro-repair effects upon translocation from the nucleus. We postulate aberrant HMGB1 expression in immune-mediated necrotising myopathy (IMNM).MethodsHerein, we compare HMGB1 expression (serolog...

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Bibliographic Details
Main Authors: Jessica Day, Sophia Otto, Kathy Cash, Preethi Eldi, Pravin Hissaria, Susanna Proudman, Vidya Limaye, John D. Hayball
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
myositis
idiopathic inflammatory myopathy
HMGB1
immune-mediated necrotising myopathy
immune-mediated necrotizing myopathy
inclusion body myositis
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00226/full

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https://www.frontiersin.org/article/10.3389/fcell.2020.00226/full

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