The Histone H3 Lysine 4 Presenter WDR5 as an Oncogenic Protein and Novel Epigenetic Target in Cancer

The Histone H3 Lysine 4 Presenter WDR5 as an Oncogenic Protein and Novel Epigenetic Target in Cancer

The histone H3 lysine 4 (H3K4) presenter WDR5 forms protein complexes with H3K4 methyltransferases MLL1-MLL4 and binding partner proteins including RBBP5, ASH2L, and DPY30, and plays a key role in histone H3K4 trimethylation, chromatin remodeling, transcriptional activation of target genes, normal b...

Full description

Bibliographic Details
Main Authors: Kebin Lu, He Tao, Xiaomin Si, Qingjuan Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Oncology
Subjects:
WDR5
MLL
histone H3K4 methylation
gene transcription
tumorigenesis
cancer therapy
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2018.00502/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2018.00502/full

Similar Items